[…] L’hydroxychloroquine (HCQ) est un médicament antipaludéen/anti-inflammatoire qui entrave le transfert endosomal des virions dans les cellules humaines. La HCQ est également un ionophore de zinc qui transporte le zinc à l’intérieur des cellules pour bloquer l’ARN polymérase dépendante de l’ARN du SRAS-CoV-2, qui est l’enzyme centrale de la réplication du virus.
Les études rétrospectives et les essais randomisés actuellement achevés ont généralement permis de découvrir ces découvertes :
1 – Lorsqu’ils sont administrés tardivement à l’hôpital et pendant de courtes périodes, les antipaludiques semblent inefficaces
Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection
Approximately 9 months of the severe acute respiratory syndrome coronavius-2 (SARS-CoV-2
[COVID-19]) spreading across the globe has led to widespread COVID-19 acute hospitalizations
and death. The rapidity and highly communicable nature of the SARS-CoV-2 outbreak
has hampered the design and executio…
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